Detalhe da pesquisa
1.
Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans.
Immunity
; 56(4): 768-782.e9, 2023 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36804958
2.
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Immunity
; 54(8): 1853-1868.e7, 2021 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34331873
3.
Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
J Virol
; 96(6): e0198221, 2022 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35045267
4.
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Chem Rev
; 121(6): 3238-3270, 2021 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33410674
5.
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease.
Bioorg Chem
; 131: 106269, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36446201
6.
NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).
J Biol Chem
; 296: 100351, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33524397
7.
Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.
J Biol Chem
; 297(2): 100909, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34171358
8.
Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2.
J Am Chem Soc
; 144(46): 21035-21045, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36356199
9.
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
J Infect Dis
; 224(Supplement_1): S1-S21, 2021 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34111271
10.
Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Crit Rev Biochem Mol Biol
; 54(1): 11-26, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30821513
11.
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
Biochemistry
; 60(39): 2925-2931, 2021 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34506130
12.
Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning.
J Chem Inf Model
; 61(6): 2537-2541, 2021 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138546
13.
Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA.
Nucleic Acids Res
; 47(14): 7676-7689, 2019 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31424549
14.
Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution.
Mol Biol Evol
; 36(4): 798-810, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30721995
15.
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.
J Virol
; 93(2)2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30381484
16.
CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy.
Proc Natl Acad Sci U S A
; 114(44): 11751-11756, 2017 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29078326
17.
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Biochemistry
; 58(35): 3711-3726, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31386353
18.
Assembly of human C-terminal binding protein (CtBP) into tetramers.
J Biol Chem
; 293(23): 9101-9112, 2018 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29700119
19.
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
J Biomol NMR
; 73(6-7): 365-374, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31243634
20.
Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
J Chem Inf Model
; 59(9): 3679-3691, 2019 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31381335